What is amyloidosis? The disease that killed ex-Pak President Pervez Musharraf

What is amyloidosis? The disease that killed ex-Pak President Pervez Musharraf

The buildup of amyloid proteins (deposits) can make it difficult for the organs and tissues to work properly.

Amyloidosis is the name for a group of rare, serious conditions caused by the buildup of an abnormal protein called amyloid in organs and tissues throughout the body.

What is amyloidosis? The disease that killed ex-Pak President Pervez Musharraf
Former Pakistan president Pervez Musharraf dies in Dubai after long illness

The buildup of amyloid proteins (deposits) can make it difficult for the organs and tissues to work properly. Without treatment, this can lead to organ failure.

Organs that may be affected include the heart, kidneys, liver, spleen, nervous system, and digestive tract.

Amyloidosis can co-occur with other illnesses in some cases. With the therapy of the other conditions, these might improve. Organ failure brought on by some forms of amyloidosis could be fatal.

Even though numerous proteins can result in amyloid plaques, only a small number of them have been directly related to serious medical issues. You may develop amyloid deposits all over your body or in just one location.

Symptoms

Symptoms of amyloidosis are often subtle. They can vary greatly depending on where the amyloid protein is collecting in the body.

It is important to note that the symptoms described below may be due to a variety of health problems.

General symptoms of amyloidosis may include:

  • Changes in skin color

  • Severe fatigue

  • Feeling of fullness

  • Joint pain

  • Low red blood cell count (anemia)

  • Shortness of breath

  • Swelling of the tongue

  • Tingling and numbness in legs and feet

  • Weak hand grip

  • Severe weakness

  • Sudden weight loss

Amyloidosis can be deadly, especially if it affects your heart or kidneys. Early diagnosis and treatment are important and can help improve survival. 

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